AA amyloidosis
AA Amyloidosis
AA amyloidosis (pronounced: A-A amy-loi-doh-sis) is a form of amyloidosis, a group of diseases characterized by the abnormal deposition of the protein amyloid in various tissues and organs of the body.
Etymology
The term "AA" in AA amyloidosis stands for "Amyloid A", referring to the specific type of amyloid protein involved. The term "amyloidosis" is derived from the Greek words "amylon" which means starch and "-osis" which denotes a medical condition.
Definition
AA amyloidosis is a systemic disease that results from the chronic inflammation or infection that leads to the overproduction of serum amyloid A (SAA) protein. This protein misfolds and forms insoluble fibrils, known as amyloid A, which are deposited in various tissues and organs, impairing their normal function.
Symptoms
The symptoms of AA amyloidosis can vary widely, depending on the organs affected. Common symptoms include fatigue, weight loss, and swelling in the legs and ankles due to kidney disease. If the heart is affected, it can lead to heart failure.
Diagnosis
Diagnosis of AA amyloidosis typically involves a combination of clinical evaluation, laboratory tests, and imaging studies. A definitive diagnosis is usually made by a biopsy of an affected organ, demonstrating the presence of amyloid deposits.
Treatment
Treatment of AA amyloidosis primarily focuses on managing the underlying condition causing the overproduction of SAA protein. This may involve anti-inflammatory medications, chemotherapy, or targeted therapies. In severe cases, organ transplantation may be necessary.
Related Terms
External links
- Medical encyclopedia article on AA amyloidosis
- Wikipedia's article - AA amyloidosis
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