5-HT1F receptor
5-HT1F receptor
The 5-HT1F receptor (pronounced as "five H T one F receptor") is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to the G protein Gi/G0 and mediates inhibitory neurotransmission, including inhibition of adenylate cyclase activity.
Etymology
The term "5-HT1F receptor" is derived from the chemical name of serotonin, 5-hydroxytryptamine (5-HT), and the classification of this receptor subtype as 1F. The 5-HT receptors are a group of G protein-coupled receptors found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The 5-HT1F receptor is one of the several different receptors for 5-HT.
Function
The 5-HT1F receptor is expressed in various tissues, with highest levels in the brain, spinal cord, and vascular smooth muscle. It plays a role in the modulation of vasoconstriction and vasodilation, and is thought to be involved in the pathophysiology of migraine.
Related Terms
- Serotonin: A neurotransmitter that is involved in the transmission of nerve impulses. Serotonin can affect mood, appetite, sleep, memory and learning, temperature regulation, and some social behavior.
- G protein-coupled receptor (GPCR): A large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses.
- Vasoconstriction: The narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels.
- Vasodilation: The widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls.
- Migraine: A type of headache characterized by recurrent attacks of severe, often unilateral, pulsating pain, usually associated with nausea, vomiting, and photophobia or phonophobia (sensitivity to light and sound).
External links
- Medical encyclopedia article on 5-HT1F receptor
- Wikipedia's article - 5-HT1F receptor
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