2F5 antibody
2F5 Antibody
The 2F5 antibody (pronounced "two-F-five antibody") is a monoclonal antibody that is known for its ability to neutralize the HIV-1 virus. It is one of the few antibodies capable of neutralizing a broad range of HIV-1 strains, making it a significant focus in the field of HIV vaccine research.
Etymology
The name "2F5" is derived from the labeling system used in the laboratory where the antibody was discovered. The "2F" indicates that it was the second flask in a series of experiments, and the "5" signifies that it was the fifth clone isolated from that flask.
Function
The 2F5 antibody targets a specific region on the gp41 protein of the HIV-1 virus known as the membrane proximal external region (MPER). By binding to this region, the 2F5 antibody prevents the virus from fusing with the host cell, thereby blocking infection.
Related Terms
- Monoclonal antibody: A type of antibody made by identical immune cells that are all clones of a unique parent cell.
- HIV-1: The most common and pathogenic strain of the human immunodeficiency virus (HIV).
- HIV vaccine: A vaccine that would either protect individuals who do not have HIV from contracting that virus, or otherwise may have a therapeutic effect for persons who have or later contract HIV/AIDS.
- gp41: A subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV).
- Membrane proximal external region (MPER): A region of the HIV-1 gp41 envelope glycoprotein that is a target for neutralizing antibodies.
External links
- Medical encyclopedia article on 2F5 antibody
- Wikipedia's article - 2F5 antibody
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