Tafenoquine succinate

Tafenoquine Succinate

Tafenoquine Succinate (pronunciation: ta-FEN-o-kwin SUK-si-nate) is an antimalarial drug used for the prevention and treatment of malaria. It is a synthetic derivative of quinine, a naturally occurring substance used for centuries in the treatment of malaria.

Etymology

The name "Tafenoquine" is derived from its chemical structure, which is a 8-aminoquinoline compound. "Succinate" refers to the salt form of the drug, which is combined with succinic acid for stability and improved absorption in the body.

Usage

Tafenoquine Succinate is used for the radical cure (prevention of relapse) of Plasmodium vivax malaria in patients aged 16 years and older. It is also used for the prophylaxis of malaria in adults for up to 6 months of continuous dosing.

Mechanism of Action

Tafenoquine Succinate works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

Side Effects

Common side effects of Tafenoquine Succinate include headache, dizziness, and gastrointestinal problems. It can also cause hemolytic anemia in people with Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency), a genetic disorder.