Simian virus 40

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Simian Virus 40 (SV40)

Simian Virus 40 (SV40), pronounced as /ˈsaɪmiən ˈvaɪrəs fɔːrti/, is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has been found to cause tumors and cancer.

Etymology

The term "Simian" is derived from the Latin word simia, meaning "ape". The virus was named "Simian Virus 40" because it is the 40th virus discovered in monkey (simian) kidney cells.

History

SV40 was first identified in 1960 in cultures of rhesus monkey kidney cells, which were being used to prepare polio vaccine. It was later found in humans and is known to persist as a latent infection.

Infection and Diseases

SV40 infection in humans is not associated with any specific disease, but it has been found in several different types of human cancers. This includes mesothelioma, brain cancer, and bone cancer. However, the role of SV40 in human disease remains controversial.

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