Dacetuzumab
| Dacetuzumab | |
|---|---|
| INN | |
| Drug class | |
| Routes of administration | Intravenous |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | Investigational |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Dacetuzumab is a monoclonal antibody that was under development for the treatment of various types of cancer, including non-Hodgkin lymphoma. It targets the CD40 molecule, which is a costimulatory protein found on the surface of many immune system cells as well as some cancer cells. The drug was developed by Seattle Genetics in collaboration with Genentech.
Mechanism of Action[edit]
Dacetuzumab works by binding to the CD40 molecule on B cells and other cells within the immune system. This binding can lead to the activation of antitumor immune responses and may also directly induce apoptosis (programmed cell death) in CD40-expressing tumor cells.
Clinical Trials[edit]
Dacetuzumab was evaluated in several clinical trials, primarily focusing on its efficacy in treating non-Hodgkin lymphoma. Early phase trials suggested some potential benefits, but later phase trials were needed to fully assess its effectiveness and safety profile.
Development and Cancellation[edit]
Despite initial promise, the development of Dacetuzumab was discontinued. The decision to halt development was based on the assessment of data from clinical trials, which suggested that the outcomes did not meet the necessary benchmarks to continue. The discontinuation was part of a broader trend in the pharmaceutical industry where certain investigational treatments are shelved if their benefit-risk profile is not sufficiently favorable.
See Also[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
