Secretor status

Secretor status is a genetic trait that determines whether a person secretes their blood type antigens into their bodily fluids, such as saliva, sweat, and tears. The secretor status of an individual can influence their susceptibility to certain diseases and conditions.

Genetics of Secretor Status

The secretor status is determined by the FUT2 gene, also known as the secrete histoblood group antigen gene. This gene is responsible for the production of the enzyme fucosyltransferase 2, which adds a fucose sugar to the precursor substance (H antigen) to form the ABO blood group antigens. Individuals with a functional FUT2 gene are known as "secretors," as they secrete ABO blood group antigens in their bodily fluids. Those with a non-functional FUT2 gene are "non-secretors," and do not secrete these antigens.

Health Implications of Secretor Status

Secretor status has been linked to susceptibility to certain diseases and conditions. For example, non-secretors are more susceptible to urinary tract infections, as the absence of blood group antigens in the urinary tract allows bacteria to adhere more easily. Conversely, secretors are more susceptible to Norovirus infections, as the virus can bind to the blood group antigens present in the gut.

Determining Secretor Status

Secretor status can be determined through genetic testing, specifically by testing for the presence of a functional FUT2 gene. This can be done through a blood test or a saliva test.

See Also

• ABO blood group system
• FUT2
• Genetic testing

References

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