Miller-Fisher syndrome

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Miller-Fisher Syndrome

Miller-Fisher Syndrome (MFS) (pronounced: mill-er fish-er sin-drome) is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, Miller-Fisher syndrome likely results from an abnormal immune response to an infection.

Etymology

The syndrome is named after Dr. C. Miller Fisher, a neurologist who first described the condition in 1956.

Symptoms

The classic triad of symptoms for Miller-Fisher Syndrome includes:

  • Ataxia: Lack of muscle control or coordination of voluntary movements.
  • Areflexia: Absence of neurologic reflexes.
  • Ophthalmoplegia: Paralysis or weakness of the eye muscles.

Causes

The exact cause of Miller-Fisher Syndrome is unknown, but it is often preceded by an infection, such as a lung infection or a gastrointestinal infection. The syndrome is thought to be an autoimmune response to these infections.

Diagnosis

Diagnosis of Miller-Fisher Syndrome is based on the presence of the classic triad of symptoms and a medical history of recent infection. Additional tests such as a lumbar puncture or nerve conduction study may be performed to confirm the diagnosis.

Treatment

Treatment for Miller-Fisher Syndrome is primarily supportive, as the condition usually resolves on its own within a few months. Treatment may include physical therapy to improve muscle strength and coordination, and medications to manage symptoms.

Prognosis

The prognosis for Miller-Fisher Syndrome is generally good, with most individuals recovering completely within six months. However, some individuals may experience residual symptoms, such as fatigue or balance problems.

See Also

External links

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