Maytansinoid
Maytansinoid
Maytansinoid (pronunciation: may-tan-sin-oid) is a class of cytotoxic agents derived from the natural product maytansine.
Etymology
The term "maytansinoid" is derived from "maytansine", a naturally occurring substance isolated from the Ethiopian shrub Maytenus serrata. The suffix "-oid" is derived from the Greek "eidos", meaning "resembling" or "like". Thus, "maytansinoid" refers to substances that resemble or are derived from maytansine.
Description
Maytansinoids are a class of highly potent cytotoxic agents that inhibit cell division by binding to tubulin, a protein involved in the formation of the mitotic spindle. They are used in the development of antibody-drug conjugates (ADCs) for the treatment of various types of cancer.
Related Terms
- Maytansine: A highly potent cytotoxic agent from which maytansinoids are derived.
- Cytotoxicity: The quality of being toxic to cells.
- Tubulin: A protein that maytansinoids bind to in order to inhibit cell division.
- Mitotic spindle: A structure involved in cell division that maytansinoids affect.
- Antibody-drug conjugate: A type of drug that maytansinoids are used to develop.
- Cancer: A disease that maytansinoids are used to treat.
External links
- Medical encyclopedia article on Maytansinoid
- Wikipedia's article - Maytansinoid
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