Low molecular weight heparin

Low Molecular Weight Heparin

Low Molecular Weight Heparin (LMWH) is a class of anticoagulant medications. They are used in the prevention of blood clots and treatment of venous thromboembolism (VTE) and in myocardial infarction.

Pronunciation

Low Molecular Weight Heparin is pronounced as loh-mo-lek-yuh-ler-weyt-hep-uh-rin.

Etymology

The term "heparin" comes from the Greek word "hepar", which means liver, as it was first isolated from dog liver. The term "low molecular weight" is used to differentiate it from unfractionated heparin, which has a higher molecular weight.

Usage

LMWHs are used to prevent and treat deep vein thrombosis or pulmonary embolism, and in the treatment of acute coronary syndrome. They are also used in the management of unstable angina and myocardial infarction.

Mechanism of Action

LMWHs work by enhancing the body's inhibition of thrombin and Factor Xa. They do this by binding to the enzyme inhibitor antithrombin III (ATIII). LMWHs, like unfractionated heparin, bind to ATIII and enhance its ability to inhibit thrombin and Factor Xa.

Related Terms

• Anticoagulant
• Venous thromboembolism
• Myocardial infarction
• Thrombin
• Factor Xa
• Antithrombin III

See Also

• Unfractionated heparin
• Warfarin
• Direct oral anticoagulants

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