Left-right determination factor 1

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(Redirected from LEFTY1)

Left-right determination factor 1 (LRD1) is a protein that plays a crucial role in the development of left-right asymmetry in vertebrates. It is encoded by the LRD1 gene and is involved in the establishment of left-right patterning during embryonic development.

Function

LRD1 is a transcription factor that regulates the expression of genes involved in left-right patterning. It is primarily expressed in the lateral plate mesoderm, a region of the developing embryo that gives rise to various organs, including the heart and lungs. LRD1 acts as a molecular switch, controlling the activation of genes that specify left-sided structures and repressing genes that specify right-sided structures.

Role in Left-Right Asymmetry

During early embryonic development, the establishment of left-right asymmetry is crucial for the proper formation and positioning of internal organs. LRD1 is one of the key factors involved in this process. It acts in coordination with other proteins and signaling pathways to ensure that organs are correctly positioned on the left or right side of the body.

Mutations in the LRD1 gene have been associated with various left-right patterning defects in humans and other vertebrates. These defects can lead to a condition known as situs inversus, where the internal organs are mirrored from their normal positions. Additionally, abnormalities in LRD1 expression have been linked to congenital heart defects and other developmental disorders.

Discovery

LRD1 was first identified as a candidate gene involved in left-right patterning through genetic studies in mice. Further research revealed its conserved role in other vertebrates, including humans. The protein structure and function of LRD1 have been extensively studied to understand its role in left-right determination.

See Also

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Contributors: Prab R. Tumpati, MD