Interleukin 19

Interleukin 19 (IL-19) is a protein that in humans is encoded by the IL19 gene. It is a member of the interleukin family of cytokines, which are proteins involved in cell signaling and immune responses.

Function

IL-19 is produced by monocytes and B cells and acts on keratinocytes and monocytes. It is involved in inflammatory responses and the regulation of cell growth. IL-19 has been shown to stimulate the production of other cytokines, including interleukin 6 and tumor necrosis factor alpha, and to induce the expression of intercellular adhesion molecule-1.

Clinical significance

IL-19 has been implicated in a number of diseases, including rheumatoid arthritis, psoriasis, and asthma. It has also been suggested that it may play a role in the development of atherosclerosis.

References

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External links

• IL19 at the US National Library of Medicine Medical Subject Headings (MeSH)

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  A demonstration of IL-19 binds to IL20 Receptor on the surface of immune cells to regulate cytokines expression
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  The anti-inflammatory effect of IL-19 in vascular diseases