Inclusion body
Inclusion Body (in-kloo-zhun bod-ee) is a term used in pathology to refer to certain structures found within the cells during microscopic examination. These structures are usually abnormal and are indicative of certain diseases or conditions.
Etymology
The term "Inclusion" comes from the Latin word inclusio, meaning "a shutting in", and "Body" from the Old English bodig, meaning "a person's physical structure".
Definition
An Inclusion Body is a distinct, often microscopic, structure seen within the cell. These bodies are usually composed of proteins and are found in the cytoplasm or nucleus of a cell. They are typically indicative of a viral infection, but can also be a result of genetic disorders or other diseases.
Types of Inclusion Bodies
There are several types of Inclusion Bodies, each associated with different diseases or conditions. Some of these include:
- Negri bodies: These are found in the nerve cells of animals infected with rabies.
- Lewy bodies: These are found in the brain cells of individuals with Parkinson's disease.
- Guarnieri bodies: These are found in cells infected with the smallpox virus.
- Russell bodies: These are found in plasma cells affected by certain conditions such as multiple myeloma.
Clinical Significance
Inclusion Bodies are significant in clinical pathology as they can provide important clues to the diagnosis of certain diseases. For example, the presence of HIV Inclusion Bodies in a patient's blood sample can confirm a diagnosis of HIV/AIDS.
See Also
External links
- Medical encyclopedia article on Inclusion body
- Wikipedia's article - Inclusion body
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