Glyburide
Glyburide
Glyburide (pronounced: /ˈɡlaɪbjʊraɪd/), also known as glibenclamide in some countries, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfa drugs.
Etymology
The term "Glyburide" is derived from its chemical name, which is 5-chloro-N-(2-{4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide. The "gly" refers to its glucose-lowering properties, and "buride" is a common suffix for sulfonylurea drugs.
Usage
Glyburide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It is used when diet and exercise alone does not result in the proper control of blood sugar levels.
Mechanism of Action
Glyburide lowers blood sugar by causing the release of your body's natural insulin. It achieves this by binding to and inhibiting the ATP-sensitive potassium channel on the pancreatic beta cells. This inhibition causes cell membrane depolarization, opening of voltage-gated calcium channels, influx of calcium, and release of insulin granules.
Side Effects
Common side effects of glyburide include nausea, upset stomach, heartburn, weight gain, and full feeling. More serious side effects include easy bleeding/bruising, stomach pain, yellowing eyes/skin, dark urine, unusual tiredness/weakness, unusual/sudden weight gain, mental/mood changes, and seizures.
Related Terms
External links
- Medical encyclopedia article on Glyburide
- Wikipedia's article - Glyburide
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