File:TumorMetabolome.jpg
Original file (770 × 619 pixels, file size: 102 KB, MIME type: image/jpeg)
Summary
| Description |
English: Illustration of important relationships between metabolome, proteome, and genome in cancerous cells. Glycolysis breaks down glucose into pyruvate, which is then fermented to lactate; pyruvate flux through the tricarboxylic acid (TCA) cycle is down-regulated in cancer cells. Pathways branching off of glycolysis, such as the pentose phosphate pathway (PPP), generate biochemical building blocks to sustain the high proliferative rate of cancer cells. Specific genetic and enzyme-level behaviors are described in the main text. Blue boxes are enzymes important in transitioning to a cancer metabolic phenotype; orange boxes are enzymes that are mutated in cancer cells. Green ovals are oncogenes that are up-regulated in cancer; red ovals are tumor suppressors that are down-regulated in cancer. Figure abbreviations: 2PG: 2-phosphoglycerate; 3PG: 3-phosphoglycerate; BPG: 1,3-bisphosphoglycerate; CoA: coenzyme A; DHAP: dihydroxyacetone phosphate; F6P: fructose-6-phosphate; FBP: fructose-1,6-bisphosphate; G3P: glyceraldehyde-3-phospate; G6P: glucose-6-phosphate; HK: hexokinase; LDHA: lactate dehydrogenase A; PFK: phosphofructokinase; PI3K: phosphatidylinositide 3-kinase |
| Date | 24 April 2014 (original upload date) |
| Source | DOI: 10.4103/1477-3163.113622; PMID: 23858297 |
| Author | Kathleen A Vermeersch, Mark P Styczynski |
| Permission (Reusing this file) |
http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=9;epage=9;aulast=Vermeersch |
Licensing
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
 | This work is free and may be used by anyone for any purpose. If you wish to use this content, you do not need to request permission as long as you follow any licensing requirements mentioned on this page.
The Wikimedia Foundation has received an e-mail confirming that the copyright holder has approved publication under the terms mentioned on this page. This correspondence has been reviewed by a Volunteer Response Team (VRT) member and stored in our permission archive. The correspondence is available to trusted volunteers as ticket #2014042510016662. If you have questions about the archived correspondence, please use the VRT noticeboard.
Ticket link: https://ticket.wikimedia.org/otrs/index.pl?Action=AgentTicketZoom&TicketNumber=2014042510016662
|
Original upload log
- 2014-04-24 06:29 Aayushraman 770×619× (104920 bytes) Uploading a file from a free published source using [[Wikipedia:File_Upload_Wizard|File Upload Wizard]]
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:33, 23 May 2014 | | 770 × 619 (102 KB) | FastilyClone | from w:File:TumorMetabolome.jpg (CM) |
File usage
The following page uses this file:
