File:Sarcoidosis - Hamazaki-Wesenberg (H-W) bodies- Lung.jpg

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Sarcoidosis - Hamazaki-Wesenberg (H-W) bodies- Lung

Although these structures may occasionally occur as inclusions within giant cells as shown in this image, they are usually not encountered as inclusions but are found extracellulary in the sinusoids of granuloma-containing lymph nodes in sarcoidosis as well as in non-granulomatous lymph nodes from individuals with sarcoidosis and other conditions.

H-W bodies are oval or spindle-shaped, range up to several microns in size, and appear yellow-brown with H&E stain . The pigment appears to be lipofuscin. Ultrastructural studies have shown that H-W bodies are giant lysosomes and residual bodies. They are acid-fast and stain with silver stains as well as a variety of other stains.When visualized with silver stains H-W bodies can be easily mistaken for budding yeasts due to clustering of individual bodies.

H&E stain - oil immersion.
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Source https://www.flickr.com/photos/pulmonary_pathology/6134889331/in/set-72157627642508464/
Author Yale Rosen
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This image, originally posted to Flickr, was reviewed on 19 November 2011 by the administrator or reviewer Leoboudv, who confirmed that it was available on Flickr under the stated license on that date.

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7 August 2011

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current03:51, 19 November 2011Thumbnail for version as of 03:51, 19 November 20112,784 × 1,901 (2.42 MB)wikimediacommons>Leoboudvretry

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