File:Fimmu-11-01648-g004.jpg
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Summary
| Description |
English: Targeting cytokine storm via the JAK-STAT pathway. During a cytokine storm, there are increased levels of IL-6 which can form a complex with mIL-6R to act on gp130. Gp130 regulates levels of IL-6, MCP-1, and GM-CSF via the JAK-STAT pathway. This could facilitate the cytokine storm. Inhibition of the JAK-STAT pathway, potentially using IL-6 inhibitors or direct inhibition of signaling, can be a therapeutic strategy (depending on the timing—indicated preferably at later stages of illness, not in early phase, or at clinical signs of cytokine storm). SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019; IL, interleukin; mIL-6R, membrane bound interleukin-6 receptor; gp 130, glycoprotein 130; MCP-1, monocytes chemoattractant protein-1; GM-CSF, granulocyte-macrophage colony-stimulating factor; JAK-STAT, janus kinase/signal transducer and activator of transcription. |
| Date | |
| Source |
Bhaskar S, Sinha A, Banach M, Mittoo S, Weissert R, Kass JS, Rajagopal S, Pai AR and Kutty S (2020) Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front. Immunol. 11:1648. https://doi.org/10.3389/fimmu.2020.01648 |
| Author | Sonu Bhaskar, Akansha Sinha, Maciej Banach, Shikha Mittoo, Robert Weissert, Joseph S. Kass, Santhosh Rajagopal, Anupama R. Pai, and Shelby Kutty |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:15, 3 February 2021 | | 953 × 639 (190 KB) | Guest2625 | Uploaded a work by Sonu Bhaskar, Akansha Sinha, Maciej Banach, Shikha Mittoo, Robert Weissert, Joseph S. Kass, Santhosh Rajagopal, Anupama R. Pai, and Shelby Kutty from Bhaskar S, Sinha A, Banach M, Mittoo S, Weissert R, Kass JS, Rajagopal S, Pai AR and Kutty S (2020) Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front. Immunol. 11:1648. https://doi.org/10.3389/fimmu.2020.01648 with Upl... |
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