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Summary
DescriptionButacaine synthesis.svg
English: Prepd from p-nitrobenzoyl chloride and γ-di-n-butylaminopropanol followed by reduction of the NO2 group to NH2: O. Kamm et al., US 1358751; Adams, Volwiler, US 1676470; A. Weston, US 2437984 (1920, 1928, 1948 all to Abbott); Burnett et al., J. Am. Chem. Soc. 59, 2248 (1937); Kaye, Roberts, ibid. 73, 4762 (1951). Toxicity study: Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1956).
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