File:A-dynamin-1--dynamin-3--and-clathrin-independent-pathway-of-synaptic-vesicle-recycling-mediated-by-elife01621f013.jpg

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Summary

Description
English: At left is CME. At right is bulk endocytosis followed by fragmentation of bulk endosomes to generate new vesicles. As membranes of bulk endosomes are expected to be enriched in SV proteins, functional SVs may be generated by this mechanism. The uncoated invaginations occurring near active zones and described by Watanabe et al. (2013a and 2013b) may represent a form of this type of clathrin-independent endocytosis. At subsequent exo–endocytic cycles, however, CME may help reestablish SV reformation with high fidelitiy.
Date
Source Image file from Wu Y, O'Toole E, Girard M, Ritter B, Messa M, Liu X, McPherson P, Ferguson S, De Camilli P (2014). "A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis". eLife. DOI:10.7554/eLife.01621. PMID 24963135. PMC: 4107917.
Author Wu Y, O'Toole E, Girard M, Ritter B, Messa M, Liu X, McPherson P, Ferguson S, De Camilli P
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24 June 2014

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current22:36, 30 September 2014Thumbnail for version as of 22:36, 30 September 2014697 × 447 (63 KB)Recitation-botAutomatic upload of media from: doi:10.7554/eLife.01621

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