Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide

Structure of Adapalene and Benzoyl Peroxide

Adapalene/benzoyl peroxide is a combination medication used in the treatment of acne vulgaris. It combines two active ingredients: adapalene, a retinoid, and benzoyl peroxide, an antimicrobial and keratolytic agent. This combination is effective in reducing inflammation, comedones, and bacterial growth associated with acne.

Mechanism of Action

Adapalene is a third-generation retinoid that modulates cellular differentiation, keratinization, and inflammatory processes. It binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. This action helps to normalize the differentiation of follicular epithelial cells, resulting in decreased microcomedone formation.

Benzoyl peroxide works by releasing free radical oxygen species that oxidize bacterial proteins, particularly in Propionibacterium acnes, the bacteria involved in acne. It also has keratolytic effects, helping to clear blocked pores and reduce sebaceous gland activity.

Clinical Use

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris in patients aged 12 years and older. It is applied once daily to affected areas after washing. The combination is particularly useful for patients with inflammatory and non-inflammatory acne lesions.

Side Effects

Common side effects include skin irritation, dryness, erythema, and peeling. These effects are usually mild to moderate and tend to decrease with continued use. Patients are advised to use a moisturizer and to avoid excessive sun exposure or use of other potentially irritating topical products.

Precautions

Patients should be advised to avoid contact with the eyes, lips, and mucous membranes. Adapalene/benzoyl peroxide should not be applied to cuts, abrasions, or eczematous skin. Caution is advised in patients with a history of hypersensitivity to any of the components.

Related pages

• Acne vulgaris
• Retinoid
• Keratolytic
• Propionibacterium acnes

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