Cinacalcet hydrochloride

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Cinacalcet hydrochloride (/sɪnəˈkælsɛt ˈhaɪdrəˌklaɪd/) is a medication used primarily in the treatment of hyperparathyroidism, a condition characterized by an overactive parathyroid gland. It is also used in the management of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis.

Etymology

The name "Cinacalcet" is derived from its chemical structure. The prefix "Cina-" is derived from the Latin word for "cinchona", a type of tree from which quinine, a treatment for malaria, is derived. The suffix "-calcet" is derived from the Latin word "calx", meaning "lime" or "limestone", which is a reference to the drug's effect on calcium levels in the body.

Pharmacology

Cinacalcet hydrochloride is a calcimimetic agent that increases the sensitivity of the calcium-sensing receptor (CaSR) to extracellular calcium. This results in a decrease in parathyroid hormone (PTH) levels, which in turn reduces serum calcium levels.

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