Encephalomalacia

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Encephalomalacia
Synonyms	Cerebral softening
Pronounce	N/A
Specialty	N/A
Symptoms	Seizures, headache, cognitive impairment, motor dysfunction
Complications	Cerebral palsy, epilepsy, hydrocephalus
Onset	Variable, depending on cause
Duration	Chronic
Types	N/A
Causes	Stroke, traumatic brain injury, infection, ischemia
Risks	Hypertension, atherosclerosis, head trauma
Diagnosis	MRI, CT scan
Differential diagnosis	Brain tumor, cerebral hemorrhage, abscess
Prevention	N/A
Treatment	Supportive care, rehabilitation, anticonvulsants
Medication	N/A
Prognosis	Variable, depends on extent of damage
Frequency	Rare
Deaths	N/A

Encephalomalacia

Encephalomalacia is a pathological condition characterized by the softening or loss of brain tissue following an injury or ischemia. This condition can result from various causes, including trauma, stroke, or infection. The affected brain tissue undergoes necrosis, leading to a loss of function in the impacted area.

Pathophysiology

Encephalomalacia occurs when there is a significant reduction in blood flow to a region of the brain, leading to ischemic necrosis. The lack of oxygen and nutrients causes the brain tissue to soften and eventually die. This process can be exacerbated by edema and the release of inflammatory mediators.

Causes

The primary causes of encephalomalacia include:

• Cerebrovascular accident (CVA) or stroke
• Traumatic brain injury (TBI)
• Infections such as encephalitis
• Brain tumors
• Surgical complications

Clinical Presentation

The symptoms of encephalomalacia depend on the location and extent of the brain tissue affected. Common symptoms include:

• Seizures
• Cognitive impairment
• Motor deficits
• Speech difficulties
• Personality changes

Diagnosis

Diagnosis of encephalomalacia is typically made using neuroimaging techniques such as MRI or CT scan. These imaging modalities can reveal areas of brain softening and necrosis.

Treatment

There is no specific treatment for encephalomalacia. Management focuses on addressing the underlying cause and providing supportive care. This may include:

• Rehabilitation therapy
• Anticonvulsants for seizure control
• Physical therapy
• Occupational therapy

Prognosis

The prognosis for individuals with encephalomalacia varies depending on the severity and location of the brain damage. Early intervention and rehabilitation can improve outcomes, but some patients may experience permanent neurological deficits.

See also

• Stroke
• Traumatic brain injury
• Cerebral edema
• Neuroimaging