Admixture mapping
Admixture Mapping (pronunciation: ad-mix-ture map-ping) is a method used in genetics to study the genetic variation and its impact on various diseases. It is also known as mapping by admixture linkage disequilibrium (MALD).
Etymology
The term "Admixture" is derived from the Latin word "admixture", meaning "to mix". In the context of genetics, it refers to the mixing of genomes from different populations. The term "Mapping" is derived from the Latin word "mappa", meaning "chart". In genetics, it refers to the process of locating specific genes on a chromosome.
Definition
Admixture Mapping is a technique used in genetic research to locate the genetic variants that cause diseases in populations that have mixed ancestry. This method is particularly useful in identifying genetic risk factors for diseases that have different prevalence rates in different populations.
Procedure
The process of Admixture Mapping involves comparing the genomes of individuals from mixed populations to identify regions where the frequency of certain genetic variants is higher than expected. These regions are then studied further to identify the specific genetic variants that are associated with the disease of interest.
Applications
Admixture Mapping has been used in various studies to identify genetic risk factors for diseases such as prostate cancer, type 2 diabetes, hypertension, and asthma. It has also been used to study the genetic basis of traits such as skin pigmentation and hair texture.
Related Terms
See Also
External links
- Medical encyclopedia article on Admixture mapping
- Wikipedia's article - Admixture mapping
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