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Tripelennamine is an antihistamine and anticholinergic of the ethylenediamine class. It is used to treat allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used to treat symptoms of the common cold and rhinorrhea.

Pharmacology

Tripelennamine is a first-generation H1 antagonist, which means it blocks the action of histamine at the H1 receptor. This helps to relieve allergic symptoms. It also has anticholinergic properties, which means it blocks the action of acetylcholine, a neurotransmitter that can cause bronchoconstriction and mucus secretion.

Side Effects

Common side effects of tripelennamine include drowsiness, dizziness, blurred vision, upset stomach, constipation, increased sweating, dry mouth/nose/throat, or changes in appetite. Serious side effects are rare, but may include mental/mood changes, difficulty urinating, or fast/irregular heartbeat.

Interactions

Tripelennamine may interact with other drugs, including other antihistamines, anticholinergics, and CNS depressants. It is important to inform your healthcare provider of all medications you are currently taking to avoid potential interactions.

Contraindications

Tripelennamine is contraindicated in patients with hypersensitivity to it or to any of its components. It should also be used with caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder-neck obstruction.

See Also

• Antihistamine
• Anticholinergic
• Ethylenediamine

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