LRP11

LRP11 is a protein that in humans is encoded by the LRP11 gene. The protein encoded by this gene is a member of the LDL receptor family, which are cell surface molecules that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. This protein acts as a receptor for apolipoprotein E and is involved in the Alzheimer's disease amyloid cascade.

Function

The LRP11 gene encodes a protein that is a member of the low-density lipoprotein receptor (LDLR) family. LDLR family members are known to play diverse roles in numerous cellular processes. The protein encoded by the LRP11 gene can bind to apolipoprotein E, suggesting a role in the clearance of lipoproteins, and is also thought to play a role in signal transduction.

Clinical significance

Mutations in the LRP11 gene have been associated with Alzheimer's disease. The protein encoded by this gene is thought to be involved in the amyloid cascade, a process that leads to the formation of plaques in the brain, a hallmark of Alzheimer's disease.

See also

• Low-density lipoprotein receptor
• Apolipoprotein E
• Alzheimer's disease

References

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External links

• NCBI Gene
• UniProt

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