GPR119

GPR119 is a G protein-coupled receptor that is expressed in various tissues, including the pancreas and the gastrointestinal tract. It is involved in the regulation of glucose homeostasis and lipid metabolism.

Function

GPR119 is activated by oleoylethanolamide, a naturally occurring bioactive lipid that has been shown to increase the secretion of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These incretin hormones are released from the intestines and stimulate insulin secretion from the pancreas in a glucose-dependent manner.

Therapeutic potential

Due to its role in glucose homeostasis and lipid metabolism, GPR119 is considered a potential therapeutic target for the treatment of type 2 diabetes and related metabolic disorders. Several GPR119 agonists have been developed and tested in clinical trials, but none have yet been approved for clinical use.

See also

• G protein-coupled receptor
• Glucagon-like peptide-1
• Glucose-dependent insulinotropic peptide
• Type 2 diabetes

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