Acquired perforating dermatosis

Acquired Perforating Dermatosis (APD) is a rare skin disorder characterized by transepidermal elimination of dermal material. It is often associated with systemic diseases, particularly renal failure and diabetes mellitus.

Overview

Acquired perforating dermatosis is a condition that primarily affects adults with chronic renal disease or diabetes. It is characterized by intensely itchy, red bumps and small nodules, and may also include larger patches that are red to brown and may be crusted. The condition is caused by the elimination of collagen or elastin through the epidermis, the outermost layer of the skin.

Symptoms

The primary symptom of acquired perforating dermatosis is the presence of small, itchy bumps on the skin. These bumps are typically red or brown and may be covered with a crust. They are most commonly found on the arms and legs, but can also appear on the torso. The itching can be severe and may interfere with sleep.

Causes

While the exact cause of acquired perforating dermatosis is unknown, it is often associated with systemic diseases. The most common of these are diabetes mellitus and chronic renal disease. Other associated conditions include hypothyroidism, liver disease, and HIV infection.

Diagnosis

Diagnosis of acquired perforating dermatosis is typically made based on the appearance of the skin lesions and the patient's medical history. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions.

Treatment

Treatment of acquired perforating dermatosis primarily involves managing the underlying systemic disease. Topical treatments, such as corticosteroids and retinoids, may be used to help manage the skin symptoms. In severe cases, other treatments such as phototherapy or systemic medications may be necessary.

See Also

• Dermatology
• Skin disease
• Diabetes mellitus
• Chronic renal disease

References

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External Links

• Wikimedia Commons - Images related to Acquired Perforating Dermatosis
• PubMed - Medical literature on Acquired Perforating Dermatosis