FUB-JWH-018

FUB-JWH-018 is a synthetic cannabinoid that is an analogue of JWH-018. It is a potent agonist of the CB₁ receptor, with a binding affinity of 1.2 nM, making it one of the most potent members of the JWH series.

Chemistry

FUB-JWH-018 is a derivative of JWH-018, in which the core indole structure is substituted with an indazole base. The structure of FUB-JWH-018 contains a terminal amide group, which is a defining feature of the FUBINACA series of synthetic cannabinoids.

Pharmacology

FUB-JWH-018 acts as a full agonist with a binding affinity of 1.2 nM at the CB₁ receptor. This makes it one of the most potent compounds in the JWH series. The CB₁ receptor is a G protein-coupled receptor located in the brain, and is one of the main targets for cannabinoids.

Effects

The effects of FUB-JWH-018 are similar to those of other synthetic cannabinoids and include euphoria, relaxation, and altered perception. However, due to its high potency, the risk of adverse effects such as anxiety, paranoia, and psychosis is increased.

Legal status

FUB-JWH-018 is illegal in many countries, including the United States, where it is classified as a Schedule I controlled substance.

See also

• JWH-018
• FUBINACA
• Synthetic cannabinoids
• Cannabinoid receptor

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