Trace amine

Class of biogenic amines related to neurotransmitters

Trace amines are a class of biogenic amines that are structurally related to classical neurotransmitters such as dopamine, norepinephrine, and serotonin. They are present in the nervous system in trace amounts, hence their name, and are thought to play a role in modulating the activity of neurotransmitter systems.

Structure and Synthesis

Phenethylamine, a trace amine

Trace amines are derived from amino acids and share a common structural motif with phenethylamine, which is the simplest trace amine. They are synthesized in the body through the decarboxylation of amino acids by the enzyme aromatic L-amino acid decarboxylase.

Function

Trace amines are believed to function as neuromodulators, influencing the release and action of classical neurotransmitters. They interact with a specific class of G protein-coupled receptors known as trace amine-associated receptors (TAARs). These receptors are involved in various physiological processes, including the regulation of mood, arousal, and cognition.

Trace Amine-Associated Receptors

TAARs are a family of receptors that are activated by trace amines. They are expressed in various tissues, including the brain, and are involved in modulating the effects of neurotransmitters. TAARs have been implicated in the pathophysiology of several neuropsychiatric disorders, such as schizophrenia and depression.

Role in Neuropsychiatric Disorders

Alterations in trace amine levels and TAAR function have been associated with various neuropsychiatric conditions. For example, abnormal trace amine signaling has been linked to attention deficit hyperactivity disorder (ADHD) and bipolar disorder. Research is ongoing to better understand the role of trace amines in these disorders and to develop potential therapeutic interventions.

Dietary Sources and Metabolism

Trace amines can also be obtained from dietary sources, as they are present in certain foods such as cheese, chocolate, and fermented products. They are metabolized in the body by enzymes such as monoamine oxidase (MAO), which also metabolizes classical neurotransmitters.

Related Pages

• Biogenic amine
• Neurotransmitter
• Phenethylamine
• Trace amine-associated receptor