Trichloroacetonitrile
Chemical compound
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Trichloroacetonitrile is a nitrile with the chemical formula CCl_CN. It is a colorless liquid that is used as an intermediate in the synthesis of various chemical compounds.
Synthesis
Trichloroacetonitrile can be synthesized through several methods. One common method involves the reaction of trichloroacetamide with phosphorus pentoxide:
Another method involves the chlorination of acetonitrile:
Applications
Trichloroacetonitrile is used as a reagent in organic synthesis. It is particularly useful in the preparation of imidates and glycosyl donors.
Imidate Formation
Trichloroacetonitrile reacts with alcohols to form trichloroacetimidates, which are useful intermediates in organic synthesis:
Glycosylation Reactions
Trichloroacetonitrile is used in the synthesis of glycosyl trichloroacetimidates, which are important in the formation of glycosidic bonds:
Safety
Trichloroacetonitrile is a hazardous chemical and should be handled with care. It is toxic if inhaled or ingested and can cause skin and eye irritation.
Related pages
References
Gallery
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Structure of trichloroacetonitrile -
Synthesis from trichloroacetamide -
Synthesis from acetonitrile -
Molecular dimensions -
Related synthesis -
Synthesis of 2-chloropyridine -
Synthesis of hydroxyketone -
Formation of trichloroacetimidate -
Glycosyl trichloroacetimidate -
Octaacetyl trehalose -
Thiogalactose synthesis
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