Lortalamine
Lortalamine is an antidepressant that was developed in the 1980s but was never marketed. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) and is structurally related to other antidepressants such as venlafaxine and desvenlafaxine.
History
Lortalamine was developed in the 1980s by the pharmaceutical company Upjohn. Despite showing promise in early clinical trials, the drug was never marketed. The reasons for this are unclear, but it may have been due to the emergence of other, more effective antidepressants around the same time.
Pharmacology
Lortalamine is a serotonin-norepinephrine reuptake inhibitor (SNRI). This means it works by increasing the levels of the neurotransmitters serotonin and norepinephrine in the brain, which can help to improve mood and relieve symptoms of depression.
Structure
Lortalamine is structurally related to other antidepressants such as venlafaxine and desvenlafaxine. These drugs are all part of the same class of medications, known as SNRIs.
Clinical Trials
Early clinical trials of lortalamine showed that it had potential as an antidepressant. However, for reasons that are not entirely clear, the drug was never marketed.
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