Nimustine
Nimustine (also known as ACNU) is a nitrosourea compound used in chemotherapy. It is classified as an alkylating agent, which means it works by damaging the DNA of cancer cells to prevent them from dividing and growing.
History[edit]
Nimustine was first synthesized in the 1970s as part of a series of nitrosourea compounds developed for their potential anti-cancer properties. It has since been used in the treatment of various types of cancer, including brain tumors, lung cancer, and leukemia.
Mechanism of Action[edit]
As an alkylating agent, nimustine works by transferring an alkyl group to the DNA molecule. This causes DNA damage, which prevents the cancer cells from dividing and growing. Nimustine is also believed to inhibit the enzyme O6-methylguanine-DNA methyltransferase, which is involved in DNA repair.
Side Effects[edit]
Like all chemotherapy drugs, nimustine can cause side effects. These can include nausea, vomiting, hair loss, and bone marrow suppression. More serious side effects can include neurotoxicity and pulmonary fibrosis.
Pharmacokinetics[edit]
Nimustine is usually administered intravenously. It is metabolized in the liver and excreted in the urine. The half-life of nimustine is approximately 2 hours.
See Also[edit]
This Chemotherapy related article is a stub. You can help WikiMD by expanding it.
Nimustine[edit]
-
Chemical structure of Nimustine -
3D space-filling model of Nimustine
Ad. Transform your life with W8MD's
GLP-1 weight loss injections special from $29.99 with insurance
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
