Solriamfetol

A medication used to treat excessive sleepiness in adults with narcolepsy or obstructive sleep apnea

Solriamfetol

Chemical structure of Solriamfetol

Solriamfetol is a medication used to treat excessive daytime sleepiness in adults with narcolepsy or obstructive sleep apnea (OSA). It is a wakefulness-promoting agent that works by inhibiting the reuptake of dopamine and norepinephrine, thereby increasing their levels in the brain.

Mechanism of Action

Solriamfetol acts as a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor. By preventing the reuptake of these neurotransmitters, solriamfetol increases their availability in the synaptic cleft, which enhances wakefulness and reduces sleepiness.

Indications

Solriamfetol is indicated for the treatment of excessive daytime sleepiness associated with:

• Narcolepsy
• Obstructive sleep apnea (OSA)

Dosage and Administration

Solriamfetol is administered orally, typically once daily in the morning. The dosage may vary based on the condition being treated and the patient's response to the medication. It is important to follow the prescribing physician's instructions regarding dosage.

Side Effects

Common side effects of solriamfetol may include:

• Headache
• Nausea
• Decreased appetite
• Anxiety
• Insomnia

Patients should be monitored for any adverse effects and report them to their healthcare provider.

Contraindications

Solriamfetol is contraindicated in patients with:

• Known hypersensitivity to solriamfetol or any of its components
• Concurrent use of monoamine oxidase inhibitors (MAOIs)

Pharmacokinetics

Solriamfetol is absorbed orally and has a half-life that allows for once-daily dosing. It is primarily excreted unchanged in the urine.

Related pages

• Narcolepsy
• Obstructive sleep apnea
• Dopamine reuptake inhibitor
• Norepinephrine reuptake inhibitor