5F-AB-PINACA

Synthetic cannabinoid

5F-AB-PINACA
INN
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CAS Number	1800101-60-3
PubChem	86273332
DrugBank
ChemSpider	52085008
KEGG

5F-AB-PINACA is a synthetic cannabinoid that has been used as an active ingredient in synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system.

Chemical structure and properties

5F-AB-PINACA is chemically classified as an indazole-based synthetic cannabinoid. Its IUPAC name is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide. The compound has a molecular formula of C₁₈H₂₆FN₃O₂ and a molecular weight of 335.42 g/mol.

The structure of 5F-AB-PINACA includes a fluorinated pentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high potency and affinity for cannabinoid receptors.

Pharmacology

5F-AB-PINACA acts as a full agonist at the CB1 receptor and CB2 receptor, with a higher affinity for the CB1 receptor. This interaction with the endocannabinoid system results in psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

The compound's high potency and efficacy at cannabinoid receptors can lead to significant psychoactive effects, which may include euphoria, altered perception, and relaxation. However, it can also cause adverse effects such as anxiety, paranoia, and tachycardia.

Legal status

The legal status of 5F-AB-PINACA varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Regulatory agencies have placed it under various schedules to restrict its distribution and use.

Health effects and safety

The use of 5F-AB-PINACA has been associated with numerous adverse health effects. These can include acute intoxication, cardiovascular complications, and neuropsychiatric symptoms. Due to its potency, there is a significant risk of overdose, which can lead to severe health consequences or death.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol