Sodium/hydrogen exchanger 6
Sodium/hydrogen exchanger 6 (also known as NHE6 or SLC9A6) is a protein that in humans is encoded by the SLC9A6 gene. It is a member of the solute carrier family of proteins, specifically the sodium/hydrogen exchanger (NHE) family. This protein functions to regulate intracellular pH and cell volume.
Function
The sodium/hydrogen exchanger 6 is an integral membrane protein found in the endosomes of cells. It functions to exchange sodium ions (Na+) for hydrogen ions (H+), effectively regulating the pH within the endosome. This is crucial for the proper functioning of the cell, as imbalances in pH can lead to cellular dysfunction and disease.
Clinical significance
Mutations in the SLC9A6 gene that encodes for NHE6 have been associated with several neurological disorders, including Christianson syndrome, a rare X-linked neurodevelopmental disorder characterized by intellectual disability, non-verbal communication, ataxia, and epilepsy.
See also
References
<references />
External links
Ad. Transform your life with W8MD's
GLP-1 weight loss injections special from $29.99 with insurance
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
