ITAM
Synonyms
ITAM, ARAM, Ag Recognition Activation Motif, Antigen Recognition Activation Motif, Immunoreceptor Tyr-Based Activation Motif, Immunoreceptor Tyrosine-Based Activation Motif, TAM, Tyrosine-Based Activation Motif
Thesaurus
ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery. ITAM, Amino Acid Sequence
- NCI Thesaurus (external)
C14047 .
This concise article on ITAM incorporates public domain text from the US National Library of Medicine.
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