Densovirinae

Densovirinae is a subfamily of viruses in the family Parvoviridae. Host organisms for Densovirinae include insects and other arthropods. There are currently 13 species in this subfamily, divided among 4 genera.

Taxonomy

The following genera are recognized:

• Ambidensovirus
• Brevidensovirus
• Iteradensovirus
• Pefudensovirus

Structure

Viruses in Densovirinae are non-enveloped, with icosahedral and round geometries, and T=1 symmetry. The diameter is around 22 nm. Genomes are linear, around 4-6kb in length.

Life Cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates endocytosis. Replication follows the rolling-hairpin model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear pore export, and viroporins. Insects and other arthropods serve as the natural host. Transmission routes are fecal-oral.

Clinical Significance

Densovirinae viruses can cause significant disease in their arthropod hosts, including insects and crustaceans. This can have knock-on effects on human activities, particularly in the case of species that are pests or that have economic importance.

References

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External links

• ICTVdB - The Universal Virus Database: Densovirinae
• Viralzone: Densovirinae
• ICTV

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