CXCL1
CXCL1 is a small cytokine belonging to the CXC chemokine family that is also known as Growth-regulated alpha protein (GRO-alpha). It is secreted by human melanocytes in response to ultraviolet light, and has been implicated in several diseases, including melanoma and non-small-cell lung carcinoma.
Structure
CXCL1 is a member of the CXC chemokine family, and is a small cytokine. It is a single, non-glycosylated, polypeptide chain containing 73 amino acids. The protein is secreted as a monomer, but can form homodimers in solution.
Function
CXCL1 is secreted by human melanocytes in response to ultraviolet light. It is a chemoattractant for neutrophils, and can also act as an angiogenic factor. The protein is expressed by macrophages, neutrophils and epithelial cells, and has effects on cells through binding to the receptors CXCR1 and CXCR2.
Clinical significance
CXCL1 has been implicated in several diseases. It is overexpressed in melanoma and non-small-cell lung carcinoma, and is associated with poor prognosis in these diseases. The protein has also been implicated in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and atherosclerosis.
See also
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
