VUF-5681

VUF-5681

VUF-5681 is a chemical compound that acts as a selective agonist for the histamine H4 receptor. It is used primarily in scientific research to study the role of the H4 receptor in various physiological and pathological processes.

Chemical Properties

VUF-5681 is a small molecule with a complex structure that allows it to bind selectively to the histamine H4 receptor. The chemical formula of VUF-5681 is C₁₇H₁₉ClN₄O, and it has a molecular weight of 330.81 g/mol.

Mechanism of Action

VUF-5681 functions by binding to the histamine H4 receptor, which is a G protein-coupled receptor (GPCR) involved in the regulation of immune responses. Activation of the H4 receptor by VUF-5681 can modulate the activity of various immune cells, including mast cells, eosinophils, and T cells.

Research Applications

VUF-5681 is used in research to explore the potential therapeutic applications of H4 receptor modulation. Studies have investigated its effects in models of allergic inflammation, asthma, and autoimmune diseases. The compound helps in understanding the role of the H4 receptor in these conditions and in evaluating the potential of H4 receptor antagonists as therapeutic agents.

Related Compounds

VUF-5681 is part of a class of compounds known as histamine receptor agonists. Other related compounds include histamine itself, which acts on multiple histamine receptors, and selective H4 receptor antagonists that are being developed for therapeutic purposes.

Related Pages

• Histamine H4 receptor
• Histamine
• G protein-coupled receptor
• Immune system