OR2A4

OR2A4

Symbol	OR2A4
HGNC ID	8181
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	7q35
Locus supplementary data	–

OR2A4 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are involved in the detection of odor molecules and are part of the G protein-coupled receptor (GPCR) superfamily.

Function

Olfactory receptors, such as OR2A4, are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is also shared by many neurotransmitter and hormone receptors. The olfactory receptor gene family is the largest in the human genome.

Gene Family

The OR2A4 gene is part of a large family of olfactory receptor genes. These genes are distributed throughout the genome and are responsible for the vast array of smells that humans can detect. The olfactory receptor gene family is highly diverse, allowing for the detection of a wide range of odorant molecules.

Location

The OR2A4 gene is located on the long arm (q) of chromosome 7, specifically at band 35. This location is part of a cluster of olfactory receptor genes.

Clinical Significance

While the primary function of OR2A4 is related to olfaction, variations in olfactory receptor genes can sometimes be associated with differences in odor perception among individuals. However, specific clinical conditions directly linked to OR2A4 have not been extensively documented.

Research

Research into olfactory receptors like OR2A4 continues to provide insights into the mechanisms of smell and the genetic basis of olfactory perception. Studies often focus on the expression patterns of these receptors and their role in the olfactory system.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 7

External Links

• OR2A4 Gene - NCBI
• OR2A4 Gene - GeneCards