SPIB

SPIB

Symbol	SPIB
HGNC ID	11254
Alternative symbols	–
Entrez Gene	6689
OMIM	601512
RefSeq	NM_003120
UniProt	Q01892
Chromosome	19q13.3
Locus supplementary data	–

SPIB is a gene that encodes a transcription factor belonging to the ETS family of transcription factors. This protein is involved in the regulation of gene expression in B cells and plasmacytoid dendritic cells.

Function

The SPIB protein functions as a transcriptional activator that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') found in the promoter regions of target genes. It plays a crucial role in the development and function of immune system cells, particularly in the differentiation of B lymphocytes and the development of plasmacytoid dendritic cells.

Clinical significance

Mutations or dysregulation of the SPIB gene have been implicated in various immune disorders and cancers, including lymphomas and leukemias. Understanding the role of SPIB in these conditions can provide insights into potential therapeutic targets.

Interactions

SPIB interacts with other proteins and transcription factors to regulate gene expression. It is known to interact with IRF4 and IRF8, which are also involved in the regulation of immune cell differentiation.

See also

• Transcription factor
• ETS family
• B cell
• Plasmacytoid dendritic cell

External links

• SPIB gene - NCBI
• SPIB protein - UniProt