OR1J2

OR1J2

Symbol	OR1J2
HGNC ID	8191
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	9q34.3
Locus supplementary data	–

OR1J2 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the G protein-coupled receptor (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of smell.

Function

The OR1J2 gene is involved in the detection of odorants in the olfactory system. Olfactory receptors, including OR1J2, are expressed in the olfactory epithelium and are responsible for the recognition and G protein-mediated transduction of odorant signals. The OR1J2 protein is a transmembrane receptor that spans the cell membrane seven times, a characteristic feature of GPCRs.

Structure

The OR1J2 protein, like other olfactory receptors, has a 7-transmembrane domain structure. This structure is typical of many neurotransmitter and hormone receptors, which allows them to interact with G proteins and initiate a cellular response upon binding to an odorant molecule.

Genetic Information

The OR1J2 gene is located on chromosome 9 at the q34.3 locus. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell.

Clinical Significance

While specific clinical implications of the OR1J2 gene are not well-documented, variations in olfactory receptor genes can affect an individual's sense of smell. Research into olfactory receptors like OR1J2 can provide insights into olfactory disorders and potential therapeutic targets for conditions affecting the sense of smell.

See Also

• Olfactory receptor family
• G protein-coupled receptor
• Chromosome 9

External Links

• OR1J2 Gene - NCBI
• OR1J2 Gene - GeneCards