ELAV-like protein 1

ELAV-like protein 1 (also known as HuR) is a member of the ELAV family of RNA-binding proteins. It is encoded by the ELAVL1 gene in humans. This protein is involved in the regulation of mRNA stability and translation, playing a crucial role in the post-transcriptional regulation of gene expression.

Function

ELAV-like protein 1 binds to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs. This binding stabilizes the mRNA and prevents its degradation, thereby influencing the expression of genes involved in cell cycle, apoptosis, and immune response.

Clinical Significance

Alterations in the expression or function of ELAV-like protein 1 have been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. Overexpression of HuR has been observed in several types of cancer, where it is associated with increased tumor growth and poor prognosis.

Interactions

ELAV-like protein 1 interacts with a variety of other proteins and RNA molecules. It is known to interact with hnRNP proteins, microRNAs, and components of the RNA-induced silencing complex (RISC), modulating their activity and function.

Research

Research on ELAV-like protein 1 is ongoing, with studies focusing on its role in gene regulation, its potential as a biomarker for disease, and its viability as a target for therapeutic intervention.

See Also

• RNA-binding protein
• Post-transcriptional regulation
• Gene expression

References

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External Links

• [ELAVL1 gene information at NCBI](https://www.ncbi.nlm.nih.gov/gene/1994)
• [UniProt entry for ELAV-like protein 1](https://www.uniprot.org/uniprot/Q15717)

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