N'-Formylkynurenine

N'-Formylkynurenine (also known as NFK) is a crucial intermediate in the metabolism of tryptophan, an essential amino acid. It is formed by the oxidation of tryptophan by the enzyme tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO).

Structure and Properties

N'-Formylkynurenine is a derivative of kynurenine, characterized by the presence of a formyl group at the nitrogen atom of the kynurenine molecule. Its molecular formula is C10H9N2O3.

Role in Tryptophan Metabolism

In the kynurenine pathway, N'-Formylkynurenine is the first stable intermediate formed from tryptophan. The conversion of tryptophan to N'-Formylkynurenine is a rate-limiting step in the pathway, catalyzed by the enzymes TDO and IDO.

File:N'-Formylkynurenine structure.png

Structure of N'-Formylkynurenine

Health Implications

Alterations in the levels of N'-Formylkynurenine have been associated with several diseases, including cancer, autoimmune diseases, and neurodegenerative diseases.

See Also

• Tryptophan
• Kynurenine pathway
• Tryptophan 2,3-dioxygenase
• Indoleamine 2,3-dioxygenase

References

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