Chromosome 11
Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.
Genes
Chromosome 11 contains about 1,300 to 1,400 genes. Some of the genes that are located on chromosome 11 include HBB: hemoglobin, beta (sickle cell anemia), MEN1: multiple endocrine neoplasia type 1, WT1: Wilms tumor 1, ATM: ataxia telangiectasia mutated (includes complementation groups A, C and D), and PAX6: paired box gene 6 (aniridia, keratitis).
Diseases and disorders
Several diseases and disorders are related to genes on chromosome 11. These include sickle cell disease, beta thalassemia, Wilms' tumor, Meckel syndrome, Alport syndrome, aniridia, Potocki-Shaffer syndrome, Smith-Magenis syndrome, Usher syndrome, and Jacobsen syndrome.
Cytogenetic band
Chromosome 11 is divided into two arms, p (short) and q (long). The p arm is acrocentric and contains many ribosomal RNA genes, while the q arm contains most of the protein-coding genes.
See also
References
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