NCOA5

NCOA5 (Nuclear Receptor Coactivator 5) is a protein that in humans is encoded by the NCOA5 gene. This protein is part of the nuclear receptor coactivator family and plays a critical role in cellular processes such as cell cycle regulation and apoptosis.

Function

NCOA5 is a coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and cyclic AMP response element-binding protein (CREB) to the transcriptional complex. It plays a role in the regulation of the cell cycle and apoptosis.

Clinical significance

Alterations in the NCOA5 gene have been associated with an increased risk of type 2 diabetes and breast cancer. Studies have shown that NCOA5 is a potential tumor suppressor gene and its downregulation may contribute to the progression of breast cancer.

See also

• Nuclear receptor
• Coactivator (genetics)
• Cell cycle
• Apoptosis
• Type 2 diabetes
• Breast cancer

References

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