Yoda1

Yoda1 is a synthetic small molecule that was first identified in a high-throughput chemical screen for Piezo1 activators. It is named after the Star Wars character Yoda, reflecting its unique and somewhat mysterious properties. Yoda1 is used in research to study the function of Piezo1 channels, which are mechanically activated ion channels involved in various physiological processes such as blood pressure regulation and cell volume control.

Chemical Structure and Properties

Yoda1 is a synthetic compound with the chemical formula C22H16N2O. It is a small molecule with a molecular weight of approximately 320.37 g/mol. The compound is typically yellow in color and is soluble in DMSO and ethanol. It is stable under normal temperatures and pressures.

Mechanism of Action

Yoda1 acts as a potent and selective activator of the Piezo1 channel. It binds to the Piezo1 protein, causing a conformational change that opens the channel and allows ions to flow through. This ion flow generates an electrical signal that can be detected and measured. The exact binding site and mechanism of action of Yoda1 are still under investigation.

Applications in Research

Yoda1 is primarily used in research to study the function and regulation of Piezo1 channels. It has been used in various experimental settings, including in vitro cell culture experiments and in vivo animal studies. Yoda1 has helped researchers gain insights into the role of Piezo1 in various physiological processes, such as blood pressure regulation, cell volume control, and mechanosensation.

Potential Therapeutic Applications

While Yoda1 is primarily a research tool, its ability to selectively activate Piezo1 channels suggests potential therapeutic applications. For example, it could potentially be used to treat conditions related to dysfunctional Piezo1 activity, such as certain types of hypertension or volume overload conditions. However, much more research is needed to fully understand the therapeutic potential of Yoda1.

Safety and Toxicity

The safety and toxicity of Yoda1 are not fully understood. As a research chemical, it is not intended for human consumption. Researchers handling Yoda1 should use appropriate safety precautions.

See Also

• Piezo1
• Mechanosensation
• Ion Channels

References

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