Aminocaproic acid

Aminocaproic Acid is a derivative of the amino acid lysine. It acts as an antifibrinolytic by inhibiting the formation and activity of plasminogen activators. It is used in the treatment of excessive bleeding resulting from systemic fibrinolysis or secondary fibrinolysis. It can also be used in cases of hereditary angioedema.

Chemistry

Aminocaproic acid, also known as epsilon-aminocaproic acid (EACA), is a synthetic derivative of the natural amino acid lysine. Its chemical formula is C6H13NO2. It is a white, crystalline substance that is soluble in water and insoluble in most organic solvents.

Pharmacology

Aminocaproic acid works by inhibiting the activation of plasminogen to plasmin, a molecule responsible for the degradation of fibrin. Fibrin is a protein that forms the framework of blood clots. By inhibiting the formation of plasmin, aminocaproic acid reduces the breakdown of fibrin, thus preventing excessive bleeding.

Clinical Use

Aminocaproic acid is used in the treatment of excessive bleeding due to general or local fibrinolysis. It is also used in the management of hereditary angioedema, although it is not a first-line treatment. Aminocaproic acid is usually administered orally or intravenously.

Side Effects

Common side effects of aminocaproic acid include nausea, diarrhea, and muscle weakness. Rare but serious side effects include blood clots, kidney dysfunction, and severe allergic reactions.

See Also

• Antifibrinolytic
• Fibrinolysis
• Hereditary angioedema
• Lysine

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