Carbestrol

Carbestrol is a synthetic nonsteroidal estrogen that was used in the past for a variety of indications but is no longer marketed due to its association with significant adverse effects.

History

Carbestrol was first synthesized in the 1930s and was used for many years in the treatment of menopausal symptoms, prostate cancer, and certain other conditions. However, it was withdrawn from the market in many countries in the 1970s and 1980s due to concerns about its safety.

Medical uses

Carbestrol was used for a variety of indications, including the treatment of menopausal symptoms, prostate cancer, and certain other conditions. However, its use was associated with significant adverse effects, and it is no longer marketed.

Adverse effects

The use of carbestrol was associated with a number of adverse effects, including blood clots, stroke, and endometrial cancer. It was also associated with an increased risk of breast cancer in women who took it for extended periods of time.

Pharmacology

Carbestrol is a synthetic nonsteroidal estrogen, which means that it mimics the effects of estrogen in the body. It binds to estrogen receptors and activates them, leading to a variety of effects.

Society and culture

The withdrawal of carbestrol from the market in many countries in the 1970s and 1980s was a significant event in the history of drug regulation. It highlighted the importance of post-marketing surveillance and the need for ongoing evaluation of the safety of drugs.

See also

• Diethylstilbestrol
• Estrogen receptor

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