Indantadol

Indantadol is a drug that is used for the treatment of pain. It is a non-opioid analgesic that is effective in treating moderate to severe pain. Indantadol is a dual inhibitor of enzymes monoamine oxidase and noradrenaline reuptake, which are involved in the transmission of pain signals in the body.

Mechanism of Action

Indantadol works by inhibiting the reuptake of noradrenaline and blocking the activity of monoamine oxidase, two enzymes that are involved in the transmission of pain signals. This dual action allows it to effectively reduce pain without the risk of addiction associated with opioid analgesics.

Uses

Indantadol is used for the treatment of moderate to severe pain. It is particularly effective in treating neuropathic pain, a type of pain caused by damage to the nerves. It can also be used to treat pain associated with osteoarthritis and rheumatoid arthritis.

Side Effects

Like all drugs, indantadol can cause side effects. These may include nausea, vomiting, dizziness, and sleepiness. In rare cases, it can cause serious side effects such as seizures and serotonin syndrome, a potentially life-threatening condition caused by excessive levels of serotonin in the brain.

Contraindications

Indantadol should not be used by people with a history of seizure disorders or those who are taking other drugs that increase the risk of seizures. It should also be used with caution in people with a history of heart disease or liver disease.

See Also

• Analgesic
• Monoamine oxidase inhibitor
• Noradrenaline reuptake inhibitor
• Neuropathic pain
• Osteoarthritis
• Rheumatoid arthritis

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